Nature Communications (Jun 2022)
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase
- Rin Mizuno,
- Hiroaki Hojo,
- Masatomo Takahashi,
- Soshiro Kashio,
- Sora Enya,
- Motonao Nakao,
- Riyo Konishi,
- Mayuko Yoda,
- Ayano Harata,
- Junzo Hamanishi,
- Hiroshi Kawamoto,
- Masaki Mandai,
- Yutaka Suzuki,
- Masayuki Miura,
- Takeshi Bamba,
- Yoshihiro Izumi,
- Shinpei Kawaoka
Affiliations
- Rin Mizuno
- Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University
- Hiroaki Hojo
- Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University
- Masatomo Takahashi
- Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
- Soshiro Kashio
- Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Sora Enya
- The Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications Research Institute International (ATR)
- Motonao Nakao
- Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
- Riyo Konishi
- Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University
- Mayuko Yoda
- Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University
- Ayano Harata
- Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University
- Junzo Hamanishi
- Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine
- Hiroshi Kawamoto
- Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University
- Masaki Mandai
- Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine
- Yutaka Suzuki
- Graduate School of Frontier Science, The University of Tokyo
- Masayuki Miura
- Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Takeshi Bamba
- Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
- Yoshihiro Izumi
- Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
- Shinpei Kawaoka
- Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-022-30926-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The presence of cancer can induce systemic disruption of the host homeostasis. Here, the authors show that different solid tumours remotely increase hepatic nicotinamide-Nmethyltransferase disrupting the host urea cycle metabolism in the liver.
