Frontiers in Genetics (Jul 2021)
Identification of HCC-Related Genes Based on Differential Partial Correlation Network
Abstract
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death, but its pathogenesis is still unclear. As the disease is involved in multiple biological processes, systematic identification of disease genes and module biomarkers can provide a better understanding of disease mechanisms. In this study, we provided a network-based approach to integrate multi-omics data and discover disease-related genes. We applied our method to HCC data from The Cancer Genome Atlas (TCGA) database and obtained a functional module with 15 disease-related genes as network biomarkers. The results of classification and hierarchical clustering demonstrate that the identified functional module can effectively distinguish between the disease and the control group in both supervised and unsupervised methods. In brief, this computational method to identify potential functional disease modules could be useful to disease diagnosis and further mechanism study of complex diseases.
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