Exploring the link: Sturge-Weber syndrome and pituitary macroadenomas: A case report and review

Razi Hashmi, MD; Mohamed Elmeligy, MD; Daniel Fabian, MD; Arun Mahtani, MD, MS; Meena Farid, DO, MS; Meheret Kinfe, MD; Paul Karroum, MD; GianPaolo Piccione, DO; Mahmoud Mahmoud, MD; Mohamed Albakri, MD; Inderbir Padda, MD, MPH

Radiology Case Reports (Nov 2024)

Exploring the link: Sturge-Weber syndrome and pituitary macroadenomas: A case report and review

Razi Hashmi, MD,
Mohamed Elmeligy, MD,
Daniel Fabian, MD,
Arun Mahtani, MD, MS,
Meena Farid, DO, MS,
Meheret Kinfe, MD,
Paul Karroum, MD,
GianPaolo Piccione, DO,
Mahmoud Mahmoud, MD,
Mohamed Albakri, MD,
Inderbir Padda, MD, MPH

Affiliations

Razi Hashmi, MD: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Mohamed Elmeligy, MD: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Daniel Fabian, MD: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Arun Mahtani, MD, MS: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Meena Farid, DO, MS: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Meheret Kinfe, MD: Department of Medicine, American University of Antigua, Staten Island, NY, USA
Paul Karroum, MD: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
GianPaolo Piccione, DO: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Mahmoud Mahmoud, MD: Department of Radiology, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Mohamed Albakri, MD: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA
Inderbir Padda, MD, MPH: Department of Internal Medicine, Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA; Corresponding author.

Journal volume & issue: Vol. 19, no. 11
pp. 5007 – 5012

Abstract

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Sturge-Weber syndrome (SWS) is a rare congenital disorder marked by facial port-wine birthmarks, neurological impairments, and ocular anomalies. Our case report describes a 20-year-old man with SWS who presented with right-sided weakness, slurred speech, and oral dyskinesia. Laboratory studies demonstrated elevated prolactin levels, and imaging confirmed a pituitary macroadenoma. While not well-documented, the association between SWS and pituitary macroadenomas is emerging based on current evidence. The potential link may involve embryological, genetic, or hormonal factors influencing the simultaneous development of these conditions. This case highlights the need for a thorough evaluation in patients with SWS, incorporating both neuroimaging and endocrine assessments to manage associated complications effectively. Further research is necessary to investigate the link between SWS and pituitary tumors. Establishing evidence-based guidelines for the screening and management of these patients will improve outcomes and provide a standardized approach to care.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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Abstract

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