Nature Communications (May 2019)
Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
- Lu Yang,
- Zaijun Ma,
- Han Wang,
- Kongyan Niu,
- Ye Cao,
- Le Sun,
- Yang Geng,
- Bo Yang,
- Feng Gao,
- Zuolong Chen,
- Zhen Wu,
- Qingqing Li,
- Yong Shen,
- Xumin Zhang,
- Hong Jiang,
- Yelin Chen,
- Rui Liu,
- Nan Liu,
- Yaoyang Zhang
Affiliations
- Lu Yang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Zaijun Ma
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Han Wang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Kongyan Niu
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Ye Cao
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Le Sun
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Yang Geng
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Bo Yang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Feng Gao
- Neurodegenerative Disorder Research Center, University of Science and Technology of China
- Zuolong Chen
- Neurodegenerative Disorder Research Center, University of Science and Technology of China
- Zhen Wu
- State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University
- Qingqing Li
- State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University
- Yong Shen
- Neurodegenerative Disorder Research Center, University of Science and Technology of China
- Xumin Zhang
- State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University
- Hong Jiang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Yelin Chen
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Rui Liu
- Singlera Genomics
- Nan Liu
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Yaoyang Zhang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-019-10136-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Post-translational protein modifications can affect lifespan and aging but age-dependent ubiquitylation changes have not yet been systematically characterized. Here, the authors analyze age-related proteome and ubiquitylome dynamics in Drosophila and identify increasing H2A ubiquitylation as a conserved aging marker.
