Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

Sunwoo Oh; Elodie Bournique; Danae Bowen; Pégah Jalili; Ambrocio Sanchez; Ian Ward; Alexandra Dananberg; Lavanya Manjunath; Genevieve P. Tran; Bert L. Semler; John Maciejowski; Marcus Seldin; Rémi Buisson

doi:10.1038/s41467-021-25203-4

Nature Communications (Aug 2021)

Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

Sunwoo Oh,
Elodie Bournique,
Danae Bowen,
Pégah Jalili,
Ambrocio Sanchez,
Ian Ward,
Alexandra Dananberg,
Lavanya Manjunath,
Genevieve P. Tran,
Bert L. Semler,
John Maciejowski,
Marcus Seldin,
Rémi Buisson

Affiliations

Sunwoo Oh: Department of Biological Chemistry, School of Medicine, University of California Irvine
Elodie Bournique: Department of Biological Chemistry, School of Medicine, University of California Irvine
Danae Bowen: Department of Biological Chemistry, School of Medicine, University of California Irvine
Pégah Jalili: Department of Biological Chemistry, School of Medicine, University of California Irvine
Ambrocio Sanchez: Department of Biological Chemistry, School of Medicine, University of California Irvine
Ian Ward: Department of Biological Chemistry, School of Medicine, University of California Irvine
Alexandra Dananberg: Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Lavanya Manjunath: Department of Biological Chemistry, School of Medicine, University of California Irvine
Genevieve P. Tran: Department of Microbiology and Molecular Genetics, UCI Center for Virus Research, School of Medicine, University of California Irvine
Bert L. Semler: Department of Microbiology and Molecular Genetics, UCI Center for Virus Research, School of Medicine, University of California Irvine
John Maciejowski: Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Marcus Seldin: Department of Biological Chemistry, School of Medicine, University of California Irvine
Rémi Buisson: Department of Biological Chemistry, School of Medicine, University of California Irvine

DOI: https://doi.org/10.1038/s41467-021-25203-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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