Nature Communications (Feb 2018)

Unattached kinetochores drive their own capturing by sequestering a CLASP

  • Caroline Kolenda,
  • Jennifer Ortiz,
  • Marina Pelzl,
  • Sarina Norell,
  • Verena Schmeiser,
  • Johannes Lechner

DOI
https://doi.org/10.1038/s41467-018-03108-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Kinetochores (KT) that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. Here the authors show that Mps1 localizes Stu1 at unattached KTs together with Slk19, causing a reorganization of the nuclear MT network that favors the capturing of unattached KT.