Nature Communications (Mar 2020)

The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage

  • Kateryna Shostak,
  • Zheshen Jiang,
  • Benoit Charloteaux,
  • Alice Mayer,
  • Yvette Habraken,
  • Lars Tharun,
  • Sebastian Klein,
  • Xinyi Xu,
  • Hong Quan Duong,
  • Andrii Vislovukh,
  • Pierre Close,
  • Alexandra Florin,
  • Florian Rambow,
  • Jean-Christophe Marine,
  • Reinhard Büttner,
  • Alain Chariot

DOI
https://doi.org/10.1038/s41467-020-15003-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 21

Abstract

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Alternate splicing of mRNA precursors has been linked to tumor development. Here the authors reveal a role of the E3 ligase RNF113A in spliceosome regulation affecting cell survival upon DNA damage.