Nature Communications (Mar 2020)
The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage
- Kateryna Shostak,
- Zheshen Jiang,
- Benoit Charloteaux,
- Alice Mayer,
- Yvette Habraken,
- Lars Tharun,
- Sebastian Klein,
- Xinyi Xu,
- Hong Quan Duong,
- Andrii Vislovukh,
- Pierre Close,
- Alexandra Florin,
- Florian Rambow,
- Jean-Christophe Marine,
- Reinhard Büttner,
- Alain Chariot
Affiliations
- Kateryna Shostak
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Zheshen Jiang
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Benoit Charloteaux
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Alice Mayer
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Yvette Habraken
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Lars Tharun
- Institute for Pathology-University Hospital
- Sebastian Klein
- Institute for Pathology-University Hospital
- Xinyi Xu
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Hong Quan Duong
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Andrii Vislovukh
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Pierre Close
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- Alexandra Florin
- Institute for Pathology-University Hospital
- Florian Rambow
- Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology and KULeuven, Department of Oncology
- Jean-Christophe Marine
- Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology and KULeuven, Department of Oncology
- Reinhard Büttner
- Institute for Pathology-University Hospital
- Alain Chariot
- Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman
- DOI
- https://doi.org/10.1038/s41467-020-15003-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 21
Abstract
Alternate splicing of mRNA precursors has been linked to tumor development. Here the authors reveal a role of the E3 ligase RNF113A in spliceosome regulation affecting cell survival upon DNA damage.
