Nature Communications (Sep 2022)
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
- Qiang Feng,
- Zhida Liu,
- Xuexin Yu,
- Tongyi Huang,
- Jiahui Chen,
- Jian Wang,
- Jonathan Wilhelm,
- Suxin Li,
- Jiwon Song,
- Wei Li,
- Zhichen Sun,
- Baran D. Sumer,
- Bo Li,
- Yang-Xin Fu,
- Jinming Gao
Affiliations
- Qiang Feng
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Zhida Liu
- Department of Pathology, University of Texas Southwestern Medical Center
- Xuexin Yu
- Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center
- Tongyi Huang
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Jiahui Chen
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Jian Wang
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Jonathan Wilhelm
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Suxin Li
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Jiwon Song
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Wei Li
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Zhichen Sun
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- Baran D. Sumer
- Department of Otolaryngology, University of Texas Southwestern Medical Center
- Bo Li
- Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center
- Yang-Xin Fu
- Department of Pathology, University of Texas Southwestern Medical Center
- Jinming Gao
- Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-32521-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Lactic acid from glycolytic metabolism of cancer cells has been associated with immune suppressive functions. Here authors show that lactate, when depart from the acidic protons, inhibits histone deacetylases in CD8 + T cells, which turns them into potent anti-tumour immune cells.
