Nature Communications (Nov 2022)
Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study
- Manina M. Etter,
- Tomás A. Martins,
- Laila Kulsvehagen,
- Elisabeth Pössnecker,
- Wandrille Duchemin,
- Sabrina Hogan,
- Gretel Sanabria-Diaz,
- Jannis Müller,
- Alessio Chiappini,
- Jonathan Rychen,
- Noëmi Eberhard,
- Raphael Guzman,
- Luigi Mariani,
- Lester Melie-Garcia,
- Emanuela Keller,
- Ilijas Jelcic,
- Hans Pargger,
- Martin Siegemund,
- Jens Kuhle,
- Johanna Oechtering,
- Caroline Eich,
- Alexandar Tzankov,
- Matthias S. Matter,
- Sarp Uzun,
- Özgür Yaldizli,
- Johanna M. Lieb,
- Marios-Nikos Psychogios,
- Karoline Leuzinger,
- Hans H. Hirsch,
- Cristina Granziera,
- Anne-Katrin Pröbstel,
- Gregor Hutter
Affiliations
- Manina M. Etter
- Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel
- Tomás A. Martins
- Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel
- Laila Kulsvehagen
- Departments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel
- Elisabeth Pössnecker
- Departments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel
- Wandrille Duchemin
- sciCORE Center for Scientific Computing, University of Basel
- Sabrina Hogan
- Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel
- Gretel Sanabria-Diaz
- Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel
- Jannis Müller
- Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel
- Alessio Chiappini
- Department of Neurosurgery, University Hospital Basel
- Jonathan Rychen
- Department of Neurosurgery, University Hospital Basel
- Noëmi Eberhard
- Department of Neurosurgery, University Hospital Basel
- Raphael Guzman
- Department of Neurosurgery, University Hospital Basel
- Luigi Mariani
- Department of Neurosurgery, University Hospital Basel
- Lester Melie-Garcia
- Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel
- Emanuela Keller
- Neurosurgical Intensive Care Unit, Department of Neurosurgery and Institute of Intensive Care Medicine, University Hospital Zurich
- Ilijas Jelcic
- Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich
- Hans Pargger
- Department of Intensive Care Medicine, University Hospital Basel
- Martin Siegemund
- Department of Intensive Care Medicine, University Hospital Basel
- Jens Kuhle
- Department of Neurology, University Hospital Basel
- Johanna Oechtering
- Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel
- Caroline Eich
- Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel
- Alexandar Tzankov
- Department of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of Basel
- Matthias S. Matter
- Department of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of Basel
- Sarp Uzun
- Department of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of Basel
- Özgür Yaldizli
- Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel
- Johanna M. Lieb
- Department of Neuroradiology, Clinic for Radiology & Nuclear Medicine, University Hospital Basel
- Marios-Nikos Psychogios
- Department of Neuroradiology, Clinic for Radiology & Nuclear Medicine, University Hospital Basel
- Karoline Leuzinger
- Division of Medical Immunology, Laboratory Medicine, University Hospital Basel
- Hans H. Hirsch
- Clinical Virology, University Hospital Basel
- Cristina Granziera
- Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel
- Anne-Katrin Pröbstel
- Departments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel
- Gregor Hutter
- Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel
- DOI
- https://doi.org/10.1038/s41467-022-34068-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Both acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairment and the severity of neurological symptoms in Sars-CoV-2 infection.
