Circulating Chemerin and Its Kinetics May Be a Useful Diagnostic and Prognostic Biomarker in Critically Ill Patients with Sepsis: A Prospective Study
Irene Karampela,
Gerasimos Socrates Christodoulatos,
Natalia Vallianou,
Dimitrios Tsilingiris,
Evangelia Chrysanthopoulou,
George Skyllas,
Georgios Antonakos,
Ioanna Marinou,
Evaggelos Vogiatzakis,
Apostolos Armaganidis,
Maria Dalamaga
Affiliations
Irene Karampela
Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari, 12462 Athens, Greece
Gerasimos Socrates Christodoulatos
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece
Natalia Vallianou
First Department of Internal Medicine, Evangelismos General Hospital, 45-47 Ipsilantou Str., 10676 Athens, Greece
Dimitrios Tsilingiris
First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 St Thomas Street, 11527 Athens, Greece
Evangelia Chrysanthopoulou
Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari, 12462 Athens, Greece
George Skyllas
Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari, 12462 Athens, Greece
Georgios Antonakos
Laboratory of Clinical Biochemistry, Medical School, National and Kapodistrian University of Athens, Attikon General University Hospital, 1 Rimini Street, Haidari, 12462 Athens, Greece
Ioanna Marinou
Laboratory of Microbiology, Sotiria Athens General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece
Evaggelos Vogiatzakis
Laboratory of Microbiology, Sotiria Athens General Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece
Apostolos Armaganidis
Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari, 12462 Athens, Greece
Maria Dalamaga
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece
Chemerin, a novel adipokine, is a potent chemoattractant molecule with antimicrobial properties, implicated in immune responses. Our aim was to investigate circulating chemerin and its kinetics, early in sepsis in critically ill patients and its association with severity and prognosis. Serum chemerin was determined in a cohort of 102 critically ill patients with sepsis during the first 48 h from sepsis onset and one week later, and in 102 age- and gender-matched healthy controls. Patients were followed for 28 days and their outcomes were recorded. Circulating chemerin was significantly higher in septic patients at onset compared to controls (342.3 ± 108.1 vs. 200.8 ± 40.1 μg/L, p p p p p p p p = 0.005; one week after: HR 10.01, 95% CI 4.32–23.20, p < 0.001). Finally, serum chemerin exhibited significant correlations with the severity scores, white blood cells, lactate, CRP and procalcitonin, as well as with biomarkers of glucose homeostasis, but not with cytokines and soluble urokinase-type plasminogen activator receptor (suPAR). Circulating chemerin is increased early in sepsis and its kinetics may have diagnostic and prognostic value in critically ill patients. Further studies are needed to shed light on the role of chemerin in sepsis.
