Drug Design, Development and Therapy (Jun 2021)
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
Abstract
Jiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang, Yan Xu Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People’s Republic of ChinaCorrespondence: Zhenning Wang; Yan XuDepartment of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People’s Republic of ChinaEmail [email protected]; [email protected]: Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream effector of the Hippo signaling pathway and a crucial co-transcription factor in the nucleus, is a promising and vital potential drug target for the treatment of GC. A series of drugs or compounds that inhibit YAP has been developed or confirmed. Therefore, this review will focus on summarizing the drugs and small-molecule inhibitors that have been reported to inhibit YAP and discuss the clinical prospects of YAP inhibitors in GC.Keywords: gastric adenocarcinoma, Yes-associated protein, Hippo pathway, small molecule inhibitor, targeted therapy
