Clinical and Biochemical Profile Associated with Renal Recovery after Acute Kidney Injury in A Mexican Population: Retrospective Cohort Study
Josué I. Ruiz-Gallardo,
Enrique Cervantes-Pérez,
Andrea Pérez de Acha-Chávez,
Guillermo A. Cervantes-Cardona,
Sol Ramírez-Ochoa,
Adriana Nápoles-Echauri,
Alejandro González-Ojeda,
Clotilde Fuentes-Orozco,
Francisco Javier Hernández-Mora,
Eduardo Gómez-Sánchez,
Jorge I. Michel-González,
Carlos Miguel González-Valencia,
Gabino Cervantes-Guevara
Affiliations
Josué I. Ruiz-Gallardo
Department of Internal Medicine, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara 44350, Mexico
Enrique Cervantes-Pérez
Department of Internal Medicine, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara 44350, Mexico
Andrea Pérez de Acha-Chávez
Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
Guillermo A. Cervantes-Cardona
Department of Philosophical, Methodological and Instrumental Disciplines, Health Sciences University Center, Universidad de Guadalajara, Guadalajara 44100, Mexico
Sol Ramírez-Ochoa
Department of Internal Medicine, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara 44350, Mexico
Adriana Nápoles-Echauri
Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
Alejandro González-Ojeda
Biomedical Research Unit 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, Guadalajara 44350, Mexico
Clotilde Fuentes-Orozco
Biomedical Research Unit 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, Guadalajara 44350, Mexico
Francisco Javier Hernández-Mora
Department of Human Reproduction, Health Sciences University Center, Universidad de Guadalajara, Guadalajara 44329, Mexico
Eduardo Gómez-Sánchez
Division of Clinical Disciplines, Health Sciences University Center, Universidad de Guadalajara, Guadalajara 44100, Mexico
Jorge I. Michel-González
Department of Internal Medicine, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara 44350, Mexico
Carlos Miguel González-Valencia
Department of Research Ethics, Hospital Hispano, Guadalajara 44140, Mexico
Gabino Cervantes-Guevara
Department of Welfare and Sustainable Development, Centro Universitario del Norte, Universidad de Guadalajara, Colotlán 46200, Mexico
Background and Objectives: Our primary objective was to study the clinical and biochemical characteristics associated with acute kidney injury (AKI) remission in a group of Mexican patients. Materials and methods: We retrospectively enrolled 75 patients who were diagnosed with AKI and separated the sample into two groups: nonremitting patients (n = 27, 36%) vs. remitting patients (n = 48, 64%). Results: We found significant relationships between nonremitting AKI and previous diagnosis of chronic kidney disease (p = 0.009), higher serum creatinine (Cr) at admission (p p p p p = 0.005), higher serum potassium on admission (p = 0.025), abnormal levels of procalcitonin (p = 0.006), and increased risk of death (p = 0.015). Conclusion: Chronic kidney disease (CKD), lower eGFR, higher levels of serum creatinine during hospitalization, higher FENa and 24-h urine protein, abnormal levels of procalcitonin, and higher serum potassium on admission were associated with nonremitting AKI. These findings may facilitate the rapid identification of patients at risk for nonremitting AKI based on clinical and biochemical characteristics. Furthermore, these findings may inform the design of timely strategies for the vigilance, prevention, and treatment of AKI.
