Nature Communications (Mar 2019)
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
- Yu Cao,
- Jimena Trillo-Tinoco,
- Rosa A. Sierra,
- Carmen Anadon,
- Wenjie Dai,
- Eslam Mohamed,
- Ling Cen,
- Tara L. Costich,
- Anthony Magliocco,
- Douglas Marchion,
- Richard Klar,
- Sven Michel,
- Frank Jaschinski,
- Richard R. Reich,
- Shikhar Mehrotra,
- Juan R. Cubillos-Ruiz,
- David H. Munn,
- Jose R. Conejo-Garcia,
- Paulo C. Rodriguez
Affiliations
- Yu Cao
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Jimena Trillo-Tinoco
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Rosa A. Sierra
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Carmen Anadon
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Wenjie Dai
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Eslam Mohamed
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Ling Cen
- Cancer Informatics Core, H. Lee Moffitt Cancer Center & Research Institute
- Tara L. Costich
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Anthony Magliocco
- Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute
- Douglas Marchion
- Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute
- Richard Klar
- Secarna Pharmaceuticals GmbH & Co. KG
- Sven Michel
- Secarna Pharmaceuticals GmbH & Co. KG
- Frank Jaschinski
- Secarna Pharmaceuticals GmbH & Co. KG
- Richard R. Reich
- Biostatistics Program, H. Lee Moffitt Cancer Center & Research Institute
- Shikhar Mehrotra
- Department of Surgery, Medical University of South Carolina
- Juan R. Cubillos-Ruiz
- Department of Obstetrics and Gynecology, Weill Cornell Medicine
- David H. Munn
- Department of Pediatrics, Georgia Cancer Center, Augusta University
- Jose R. Conejo-Garcia
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- Paulo C. Rodriguez
- Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-09263-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting in repression of T-bet and consequent inhibition of CD8+ T cell function.”
