Nature Communications (Feb 2019)

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

  • Yamei Han,
  • Zhimin Hu,
  • Aoyuan Cui,
  • Zhengshuai Liu,
  • Fengguang Ma,
  • Yaqian Xue,
  • Yuxiao Liu,
  • Feifei Zhang,
  • Zehua Zhao,
  • Yanyan Yu,
  • Jing Gao,
  • Chun Wei,
  • Jingya Li,
  • Jing Fang,
  • Jia Li,
  • Jian-Gao Fan,
  • Bao-Liang Song,
  • Yu Li

DOI
https://doi.org/10.1038/s41467-019-08585-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expression. This is protective against steatosis in diabetic mice.