PLoS ONE (Jan 2021)

A novel quantitative analysis method for idiopathic epiretinal membrane.

  • Davide Allegrini,
  • Giovanni Montesano,
  • Stefania Marconi,
  • Nicoletta Rosso,
  • Giovanni Ometto,
  • Raffaele Raimondi,
  • Ferdinando Auricchio,
  • Panagiotis Tsoutsanis,
  • Francesco Semeraro,
  • Matteo Cacciatori,
  • David P Crabb,
  • Mario R Romano

DOI
https://doi.org/10.1371/journal.pone.0247192
Journal volume & issue
Vol. 16, no. 3
p. e0247192

Abstract

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PurposeTo introduce a novel method to quantitively analyse in three dimensions traction forces in a vast area of the ocular posterior pole.MethodsRetrospective analysis of 14 eyes who underwent peeling surgery for idiopathic, symptomatic and progressive epiretinal membrane. The technique measures the shift in position of vascular crossings after surgery from a fixed point, which is the retinal pigmented epithelium. This shift is defined as the relaxation index (RI) and represents a measure of the postoperative movement of the retina due to released traction after surgery.ResultsBest-corrected visual acuity was significantly better than baseline at all follow ups while the RI had its maximum value at baseline. Moreover, we found a significant correlation between best-corrected visual acuity at 6 months and RI at baseline.ConclusionWhile all previous published methods focused on bi-dimensional changes observed in a small region, this study introduces a three-dimensional assessment of tractional forces. Future integration of RI into built-in processing software will allow systematic three-dimensional measurement of intraretinal traction.