Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

Locke D. Uppendahl; Carly M. Dahl; Jeffrey S. Miller; Martin Felices; Melissa A. Geller

doi:10.3389/fimmu.2017.01825

Frontiers in Immunology (Jan 2018)

Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

Locke D. Uppendahl,
Carly M. Dahl,
Jeffrey S. Miller,
Martin Felices,
Melissa A. Geller

Affiliations

Locke D. Uppendahl: Department of Obstetrics, Gynecology and Women’s Health, Division of Gynecologic Oncology, University of Minnesota School of Medicine, Minneapolis, MN, United States
Carly M. Dahl: University of Minnesota School of Medicine, Minneapolis, MN, United States
Jeffrey S. Miller: Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota School of Medicine, Minneapolis, MN, United States
Martin Felices: Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota School of Medicine, Minneapolis, MN, United States
Melissa A. Geller: Department of Obstetrics, Gynecology and Women’s Health, Division of Gynecologic Oncology, University of Minnesota School of Medicine, Minneapolis, MN, United States

DOI: https://doi.org/10.3389/fimmu.2017.01825
Journal volume & issue: Vol. 8

Abstract

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Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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