Photon-directed multiplexed enzymatic DNA synthesis for molecular digital data storage

Howon Lee; Daniel J. Wiegand; Kettner Griswold; Sukanya Punthambaker; Honggu Chun; Richie E. Kohman; George M. Church

doi:10.1038/s41467-020-18681-5

Nature Communications (Oct 2020)

Photon-directed multiplexed enzymatic DNA synthesis for molecular digital data storage

Howon Lee,
Daniel J. Wiegand,
Kettner Griswold,
Sukanya Punthambaker,
Honggu Chun,
Richie E. Kohman,
George M. Church

Affiliations

Howon Lee: Department of Genetics, Harvard Medical School
Daniel J. Wiegand: Department of Genetics, Harvard Medical School
Kettner Griswold: Department of Genetics, Harvard Medical School
Sukanya Punthambaker: Department of Genetics, Harvard Medical School
Honggu Chun: Department of Biomedical Engineering, Korea University
Richie E. Kohman: Department of Genetics, Harvard Medical School
George M. Church: Department of Genetics, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-18681-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Writing data in DNA is still a bottleneck due to the reliance on chemical synthesis methods. Here the authors report multiplexed enzymatic DNA synthesis using maskless photolithography.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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