FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Minh Binh Nguyen; Idan Cohen; Vinod Kumar; Zijian Xu; Carmit Bar; Katherine L. Dauber-Decker; Pai-Chi Tsai; Pauline Marangoni; Ophir D. Klein; Ya-Chieh Hsu; Ting Chen; Marja L. Mikkola; Elena Ezhkova

doi:10.1038/s41467-018-04399-y

Nature Communications (Jun 2018)

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Minh Binh Nguyen,
Idan Cohen,
Vinod Kumar,
Zijian Xu,
Carmit Bar,
Katherine L. Dauber-Decker,
Pai-Chi Tsai,
Pauline Marangoni,
Ophir D. Klein,
Ya-Chieh Hsu,
Ting Chen,
Marja L. Mikkola,
Elena Ezhkova

Affiliations

Minh Binh Nguyen: Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Idan Cohen: Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Vinod Kumar: Developmental Biology Program, Institute of Biotechnology, University of Helsinki
Zijian Xu: National Institute of Biological Sciences
Carmit Bar: Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Katherine L. Dauber-Decker: Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Pai-Chi Tsai: Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute
Pauline Marangoni: Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco
Ophir D. Klein: Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco
Ya-Chieh Hsu: Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute
Ting Chen: National Institute of Biological Sciences
Marja L. Mikkola: Developmental Biology Program, Institute of Biotechnology, University of Helsinki
Elena Ezhkova: Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-018-04399-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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