OncoTargets and Therapy (Oct 2016)
Primary adenoid cystic carcinoma of the trachea with thyroid invasion: a case report and literature review
Abstract
Dianjun Qi,1 Liang Feng,2 Jian Li,3 Bing Liu,4 Qingfu Zhang5 1Department of General Practice, 2Department of Breast Surgery, 3Department of Radiology, 4Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, 5Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, People’s Republic of China Abstract: Primary adenoid cystic carcinoma (ACC) of the trachea with thyroid invasion is very rare. In this report, we present a 46-year-old man with primary ACC of the trachea with thyroid invasion. ACC invasion of the thyroid is very rare and is easily misdiagnosed. The patient sought consultation due to a 6-month history of dysphagia and associated dyspnea. A contrast-enhanced computed tomography scan obtained at the time of admission revealed bilateral thyroid masses and tracheal wall thickening. The thyroid masses were fused to the trachea and the esophagus without discernible borders, intraoperatively. Frozen pathology suggested poorly differentiated cancer, and a bilateral partial thyroidectomy was performed. Postoperative pathology revealed primary tracheal ACC with thyroid invasion. The patient died 1 month after surgery. We have also summarized the literature on the clinical presentation, diagnosis, and treatment of thyroid-invasive ACC. Keywords: trachea, adenoid cystic carcinoma, thyroid
