Nature Communications (Feb 2017)
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
- K. L. Jønsson,
- A. Laustsen,
- C. Krapp,
- K. A. Skipper,
- K. Thavachelvam,
- D. Hotter,
- J. H. Egedal,
- M. Kjolby,
- P. Mohammadi,
- T. Prabakaran,
- L. K. Sørensen,
- C. Sun,
- S. B. Jensen,
- C. K. Holm,
- R. J. Lebbink,
- M. Johannsen,
- M. Nyegaard,
- J. G. Mikkelsen,
- F. Kirchhoff,
- S. R. Paludan,
- M. R. Jakobsen
Affiliations
- K. L. Jønsson
- Department of Biomedicine, Aarhus University
- A. Laustsen
- Department of Biomedicine, Aarhus University
- C. Krapp
- Department of Biomedicine, Aarhus University
- K. A. Skipper
- Department of Biomedicine, Aarhus University
- K. Thavachelvam
- Department of Biomedicine, Aarhus University
- D. Hotter
- Ulm University Medical Center, Institute of Molecular Virology
- J. H. Egedal
- Department of Biomedicine, Aarhus University
- M. Kjolby
- Department of Biomedicine, Aarhus University
- P. Mohammadi
- New York Genome Center
- T. Prabakaran
- Department of Biomedicine, Aarhus University
- L. K. Sørensen
- Department of Forensic Medicine, Aarhus University Hospital
- C. Sun
- Department of Biomedicine, Aarhus University
- S. B. Jensen
- Department of Biomedicine, Aarhus University
- C. K. Holm
- Department of Biomedicine, Aarhus University
- R. J. Lebbink
- University Medical Center Utrecht
- M. Johannsen
- Department of Forensic Medicine, Aarhus University Hospital
- M. Nyegaard
- Department of Biomedicine, Aarhus University
- J. G. Mikkelsen
- Department of Biomedicine, Aarhus University
- F. Kirchhoff
- Ulm University Medical Center, Institute of Molecular Virology
- S. R. Paludan
- Department of Biomedicine, Aarhus University
- M. R. Jakobsen
- Department of Biomedicine, Aarhus University
- DOI
- https://doi.org/10.1038/ncomms14391
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.
