Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

Yusuke Mii; Takayoshi Yamamoto; Ritsuko Takada; Shuji Mizumoto; Makoto Matsuyama; Shuhei Yamada; Shinji Takada; Masanori Taira

doi:10.1038/s41467-017-02076-0

Nature Communications (Dec 2017)

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

Yusuke Mii,
Takayoshi Yamamoto,
Ritsuko Takada,
Shuji Mizumoto,
Makoto Matsuyama,
Shuhei Yamada,
Shinji Takada,
Masanori Taira

Affiliations

Yusuke Mii: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Takayoshi Yamamoto: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Ritsuko Takada: National Institute for Basic Biology and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences
Shuji Mizumoto: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University
Makoto Matsuyama: Division of Molecular Genetics, Shigei Medical Research Institute
Shuhei Yamada: Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University
Shinji Takada: National Institute for Basic Biology and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences
Masanori Taira: Department of Biological Sciences, Graduate School of Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-017-02076-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 19

Abstract

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Wnt proteins mediate embryonic development but how protein localization and patterning is regulated is unclear. Here, the authors show that distinct structures with different heparan sulfate modifications (‘N-sulfo-rich’ and ‘N-acetyl-rich’) regulate cellular localization and signal transduction of Wnt8 in Xenopus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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