A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease

• Zheng Fu,
• Jian Wang,
• Zheng Wang,
• Ying Sun,
• Jian Wu,
• Yongchen Zhang,
• Xingxiang Liu,
• Zhen Zhou,
• Likun Zhou,
• Chen-Yu Zhang,
• Yongxiang Yi,
• Xinyi Xia,
• Lin Wang,
• Xi Chen

Affiliations

Zheng Fu

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University

Jian Wang

Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Zheng Wang

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Ying Sun

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University

Jian Wu

COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine

Yongchen Zhang

Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine

Xingxiang Liu

Huai’an Fourth Hospital

Zhen Zhou

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University

Likun Zhou

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University

Chen-Yu Zhang

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University

Yongxiang Yi

Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine

Xinyi Xia

COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine

Lin Wang

Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Xi Chen

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Chemistry and Biomedicine Innovation Center, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University