Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Oct 1999)
The comparison of the effects of two Insulin therapy methods on fetal macrosomia due to maternal diabetes
Abstract
Objective: One of the major side effects of maternal diabetes is that the fetus weights to be more than 4000gr named as macrosomia. A suitable control of the blood sugar can strongly decrease the diabetes complications, such as macrosomia. We tried to compare two insulin therapy methods with regard to macrosomic effects on the fetus in order to suggest the most practical and suitable one. Methods: The subjects were 200 pregnant women below 32 weeks of pregnancy with a blood sugar level over 105 mg/dl before having breakfast. They were divided into two groups, each of which subjected to one of the insulin regulation methods. In the first method, the blood sugar level was measured six times a day, being followed by four different patterns of insulin prescription. In the second method, blood sugar level was measured three times a day, and the prescribed insulin was an integration of 2/3 NPH insulin and 1/3 crystal insulin. Data were collected with using questionnaire before and after labor. Findings: The rate of macrosomia and the average weight in the first group was 7.6%, (3538±588 g) and in the second group was 8.6%, (3563±467 g). There was no meaningful difference between the two groups in terms of the average weight, and other effects of diabetes on mother, fetus, infant and cesarean rate. Conclusion: Therefore, these methods of insulin therapy, in terms of the special macrosomia diabetic effects of diabetes are the same, but in second method, however, is much more advantageous since measuring of the blood sugar level is three rimes less than other one.
