Nature Communications (Jun 2020)

High flavivirus structural plasticity demonstrated by a non-spherical morphological variant

  • Seamus R. Morrone,
  • Valerie S. Y. Chew,
  • Xin-Ni Lim,
  • Thiam-Seng Ng,
  • Victor A. Kostyuchenko,
  • Shuijun Zhang,
  • Melissa Wirawan,
  • Pau-Ling Chew,
  • Jaime Lee,
  • Joanne L. Tan,
  • Jiaqi Wang,
  • Ter Yong Tan,
  • Jian Shi,
  • Gavin Screaton,
  • Marc C. Morais,
  • Shee-Mei Lok

DOI
https://doi.org/10.1038/s41467-020-16925-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.