FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells

Maha Said; Viviana Barra; Elisa Balzano; Ibtissam Talhaoui; Franca Pelliccia; Simona Giunta; Valeria Naim

doi:10.1038/s42003-022-04360-2

Communications Biology (Dec 2022)

FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells

Maha Said,
Viviana Barra,
Elisa Balzano,
Ibtissam Talhaoui,
Franca Pelliccia,
Simona Giunta,
Valeria Naim

Affiliations

Maha Said: CNRS UMR9019, Université Paris-Saclay, Gustave Roussy
Viviana Barra: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo
Elisa Balzano: Department of Biology & Biotechnology “Charles Darwin”, University of Rome Sapienza
Ibtissam Talhaoui: CNRS UMR9019, Université Paris-Saclay, Gustave Roussy
Franca Pelliccia: Department of Biology & Biotechnology “Charles Darwin”, University of Rome Sapienza
Simona Giunta: Department of Biology & Biotechnology “Charles Darwin”, University of Rome Sapienza
Valeria Naim: CNRS UMR9019, Université Paris-Saclay, Gustave Roussy

DOI: https://doi.org/10.1038/s42003-022-04360-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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