Anti-TNF-α and hydralazine drug-induced lupus

Abstract

AbstractDrug-induced lupus is a rare drug reaction featuring the same symptoms as idiopathic lupus erythematosus. Recently, with the introduction of new medicines in clinical practice, an increase in the number of illness-triggering implicated drugs has been reported, with special emphasis on anti-TNF-α drugs. In the up-to-date list, almost one hundred medications have been associated with the occurrence of drug-induced lupus. The authors present two case reports of the illness induced respectively by hydralazine and infliximab, addressing the clinical and laboratorial characteristics, diagnosis, and treatment.

Keywords

• Acetyl-CoA C-Acetyltransferase
• Acetylation
• Autoimmunity
• Hydralazine
• Lupus erythematosus, cutaneous
• Tumor necrosis factor-alpha