Suppression of telomere capping defects of Saccharomyces cerevisiae yku70 and yku80 mutants by telomerase

Cory L Holland; Brian A Sanderson; James K Titus; Monica F Weis; Angelica M Riojas; Eric Malczewskyj; Brian M Wasko; L Kevin Lewis

doi:10.1093/g3journal/jkab359

G3: Genes, Genomes, Genetics (Oct 2021)

Suppression of telomere capping defects of Saccharomyces cerevisiae yku70 and yku80 mutants by telomerase

Cory L Holland,
Brian A Sanderson,
James K Titus,
Monica F Weis,
Angelica M Riojas,
Eric Malczewskyj,
Brian M Wasko,
L Kevin Lewis

Affiliations

Cory L Holland: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
Brian A Sanderson: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
James K Titus: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
Monica F Weis: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
Angelica M Riojas: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
Eric Malczewskyj: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
Brian M Wasko: ORCiD; Department of Biology and Biotechnology, University of Houston-Clear Lake, Houston, TX, 77058, USA
L Kevin Lewis: Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA

DOI: https://doi.org/10.1093/g3journal/jkab359
Journal volume & issue: Vol. 11, no. 12

Abstract

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AbstractThe Ku complex performs multiple functions inside eukaryotic cells, including protection of chromosomal DNA ends from degradation and fusion events, recruitment of telomerase, and repair of double-strand breaks (DSBs). Inactivation of Ku complex genes YKU70YKU80Saccharomyces cerevisiaeykuykuTLC1yku70TLC1yku

Published in G3: Genes, Genomes, Genetics

ISSN: 2160-1836 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://academic.oup.com/g3journal

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