Communications Biology (Jan 2021)
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
- So-mi Kang,
- Min-Ho Yoon,
- Jinsook Ahn,
- Ji-Eun Kim,
- So Young Kim,
- Seock Yong Kang,
- Jeongmin Joo,
- Soyoung Park,
- Jung-Hyun Cho,
- Tae-Gyun Woo,
- Ah-Young Oh,
- Kyu Jin Chung,
- So Yon An,
- Tae Sung Hwang,
- Soo Yong Lee,
- Jeong-Su Kim,
- Nam-Chul Ha,
- Gyu-Yong Song,
- Bum-Joon Park
Affiliations
- So-mi Kang
- Department of Molecular Biology, College of Natural Science, Pusan National University
- Min-Ho Yoon
- Department of Molecular Biology, College of Natural Science, Pusan National University
- Jinsook Ahn
- Department of Food Science, College of Agricultural Science, Seoul National University
- Ji-Eun Kim
- Department of Pharmacy, College of Pharmacy, Chungnam National University
- So Young Kim
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation
- Seock Yong Kang
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation
- Jeongmin Joo
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation
- Soyoung Park
- Department of Molecular Biology, College of Natural Science, Pusan National University
- Jung-Hyun Cho
- Department of Molecular Biology, College of Natural Science, Pusan National University
- Tae-Gyun Woo
- Department of Molecular Biology, College of Natural Science, Pusan National University
- Ah-Young Oh
- Department of Molecular Biology, College of Natural Science, Pusan National University
- Kyu Jin Chung
- Department of Pharmacy, College of Pharmacy, Chungnam National University
- So Yon An
- Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University
- Tae Sung Hwang
- Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University
- Soo Yong Lee
- Cardiovascular Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital
- Jeong-Su Kim
- Cardiovascular Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital
- Nam-Chul Ha
- Department of Food Science, College of Agricultural Science, Seoul National University
- Gyu-Yong Song
- Department of Pharmacy, College of Pharmacy, Chungnam National University
- Bum-Joon Park
- Department of Molecular Biology, College of Natural Science, Pusan National University
- DOI
- https://doi.org/10.1038/s42003-020-01540-w
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 11
Abstract
Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.
