Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

Szymon P. Kordon; Przemysław Dutka; Justyna M. Adamska; Sumit J. Bandekar; Katherine Leon; Satchal K. Erramilli; Brock Adams; Jingxian Li; Anthony A. Kossiakoff; Demet Araç

doi:10.1038/s41467-023-36312-7

Nature Communications (Feb 2023)

Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

Szymon P. Kordon,
Przemysław Dutka,
Justyna M. Adamska,
Sumit J. Bandekar,
Katherine Leon,
Satchal K. Erramilli,
Brock Adams,
Jingxian Li,
Anthony A. Kossiakoff,
Demet Araç

Affiliations

Szymon P. Kordon: Department of Biochemistry and Molecular Biology, The University of Chicago
Przemysław Dutka: Department of Biochemistry and Molecular Biology, The University of Chicago
Justyna M. Adamska: Department of Biochemistry and Molecular Biology, The University of Chicago
Sumit J. Bandekar: Department of Biochemistry and Molecular Biology, The University of Chicago
Katherine Leon: Department of Biochemistry and Molecular Biology, The University of Chicago
Satchal K. Erramilli: Department of Biochemistry and Molecular Biology, The University of Chicago
Brock Adams: Department of Biochemistry and Molecular Biology, The University of Chicago
Jingxian Li: Department of Biochemistry and Molecular Biology, The University of Chicago
Anthony A. Kossiakoff: Department of Biochemistry and Molecular Biology, The University of Chicago
Demet Araç: Department of Biochemistry and Molecular Biology, The University of Chicago

DOI: https://doi.org/10.1038/s41467-023-36312-7
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

Read online

Adhesion GPCRs have numerous functions, ligands and isoforms. Here, Kordon et al. report synthetic antibodies that both modulate aGPCR signaling in an isoform-specific manner, and break receptor interactions in a ligand-specific manner

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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