Novel vascular strategies on polyetheretherketone modification in promoting osseointegration in ovariectomized rats

Xiao Wang; Jingshu Guo; Jin Wen; Xiangkai Zhang; Lingyan Cao; Deliang Zeng; Xuanyong Liu; Xinquan Jiang

Materials & Design (Apr 2021)

Novel vascular strategies on polyetheretherketone modification in promoting osseointegration in ovariectomized rats

Xiao Wang,
Jingshu Guo,
Jin Wen,
Xiangkai Zhang,
Lingyan Cao,
Deliang Zeng,
Xuanyong Liu,
Xinquan Jiang

Affiliations

Xiao Wang: Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
Jingshu Guo: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Jin Wen: Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
Xiangkai Zhang: Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, China
Lingyan Cao: Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
Deliang Zeng: Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
Xuanyong Liu: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Corresponding author.
Xinquan Jiang: Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Corresponding author at: Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

Journal volume & issue: Vol. 202
p. 109526

Abstract

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The primary stability and final osseointegration of endosseous implants may be hindered by certain abnormal bone-metabolism conditions, such as osteoporosis. Polyetheretherketone (PEEK), which shows similar adjustable elastic modulus with cortical bone, is considered to be an ideal candidate to replace metallic implants, especially for osteoporotic bone. However, the bioinertness and poor osteogenic properties of PEEK fail to pave the way for clinical application. Here, a novel coating (EBE-SrSi) with bioactive elements on PEEK implants was generated via electron beam evaporation (EBE) to enhance the rapid osseointegration by inducing osteogenesis, as well as angiogenesis. In vitro, the dual Sr/Si ion modified surface exihibits a better osteo-inductive effect on the BMSCs derived from ovariectomized rats (rBMSCs-OVX). Furthermore, the modified samples also stimulated human umbilical vein endothelial cells (HUVECs) migration and angiogenesis. Finally, in the OVX rat bonedefect model, the EBE-SrSi group exhibited faster bone formation which might be attributed to the impact of the transformation of endogenous MSC accompanied by promotion of the angiogenic activity of endothelial cells. Our results unveiled the potential of dual Sr/Si modified PEEK in promoting osseointegration under osteoporotic conditions and will further broaden the adoption of PEEK materials in dental fields.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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