Do Gene Polymorphisms Play a Role in Newborn Hyperbilirubinemia?

Abstract

Polymorphisms of the uridine-diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene, hepatic solute carrier organic anion transporter 1B1/B3 (SLCO1B1/3) gene, and glutathione S-transferase (GST) gene have been associated with significant hyperbilirubinemia in some populations. This study aims to determine whether the variation of UGT1A1, SLCO1B1/3 and GST genes play an important role in neonatal hyperbilirubinemia in Turkish newborn infants.

Keywords

• neonatal hyperbilirubinemia
• gene polymorphisms
• ugt1a1
• slco1b1/b3
• gst