SLEEP DISORDERS IN THE EARLY RECOVERY PERIOD OF CEREBRAL STROKE AND THE POSSIBILITY OF CHRONOTHERAPEUTICAL CORRECTION

Abstract

Sleep disorders in patients in the early rehabilitation period of stroke were studied. It was shown the effectiveness of the chronotherapy (phototherapy and drug Melaxen®) on the dynamics of sleep disturbance, cognitive, emotional and movement disorders, quality of life in the rehabilitation of stroke patients. The concentration of brain-derived neurotrophic factor (BDNF) in blood serum and the level of 6-SOMT in the urine were assessed. The purpose of research was to study the effectiveness of chronotherapy (phototherapy and Melaxen®) on the dynamics of sleep disturbances, cognitive and emotional disorders, BDNF and the level of secretion of melatonin (6-SOMT) in patients after cerebral stroke in the early recovery periods. Materials and methods. We examined 112 patients in the early rehabilitation period of stroke (mean age of 58.0 ± 9.74 years). The main groups of patients along with standard treatment received phototherapy and Melaxen® 3мг/day for 3 months. Sleep quality, cognitive and emotional status, concentration of BDNF in blood serum and night urinary level of 6-sulfatoxymelatonin were assessed. The results and conclusion. The study demonstrated the high efficacy of chronotherapy with Melaxen® in the rehabilitation of patients in early recovery period of stroke. Chronotherapy significantly increased the concentration of BDNF and 6-SOMT, improved cognitive function and sleep parameters, reduced the level of anxiety and depression in the early recovery period of stroke.

Keywords

• stroke
• medical rehabilitation
• chronotherapy
• melaxen®
• sleep disoders
• depression
• brain-derived neurotrophic factor bdnf
• 6-somt