Nature Communications (Oct 2020)

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

  • Giljae Lee,
  • Hyun Ju You,
  • Jasmohan S. Bajaj,
  • Sae Kyung Joo,
  • Junsun Yu,
  • Seoyeon Park,
  • Hyena Kang,
  • Jeong Hwan Park,
  • Jung Ho Kim,
  • Dong Hyeon Lee,
  • Seonhwa Lee,
  • Won Kim,
  • GwangPyo Ko

DOI
https://doi.org/10.1038/s41467-020-18754-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in individuals without obesity. Here, gut microbiome analysis using a biopsy-proven NAFLD cohort reveal distinct signatures of microbiome-metabolites associated with significant fibrosis in patients with NAFLD without obesity.