Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT)

Abstract

Objectives and aim: Serum albumin level is mainly a marker of nutritional status in both healthy subjects and patients with malignancies. Our objective was to investigate the association of pre-transplant serum albumin levels with prognosis in autologous HSCT recipients. Materials and methods: We retrospectively analysed 106 patients’ data who had undergone autologous HSCT diagnosed with multiple myeloma, Hodgkin Lymphoma and Non-Hodgkin Lymphoma. Serum albumin, phosphorus, D-dimer and uric acid, CD34+ cell count, BMI, presence of neutropenic fever of 106 patients were evaluated. The patients’ data were obtained from the file records. Results: 33 (31.1%) of the patients were female, and 73 (68.9%) were male. The diagnosis of the patients were; Hodgkin Lyphoma (33 patients, 31.1%), non-Hodgkin lymphoma (34 patients, 32.1%), and multiple myeloma (39 patients, 36.8%). The median age was found 42 years (min-max: 17-67). Univariate and multivariate analysis showed that low albumin levels (0.05). Conclusion: Pre-transplant serum albumin levels may be associated with poor outcomes in patients who had undergone autologous hematopoietic stem cell transplantation regardless with primary diagnosis.

Keywords

• albumin
• autoHSCT
• survival
• lymphoma
• multiple myeloma