Radiation-induced meningiomas (RIM) in adults: A single-centre retrospective experience

Stamatios Banos; Mary Solou; Ioannis Ydreos; Evangelos K. Papadopoulos; Georgios Savvanis; Anastasios A. Politis; Lampis C. Stavrinou; Maria M. Gavra; Efstathios J. Boviatsis

Brain and Spine (Jan 2023)

Radiation-induced meningiomas (RIM) in adults: A single-centre retrospective experience

Stamatios Banos,
Mary Solou,
Ioannis Ydreos,
Evangelos K. Papadopoulos,
Georgios Savvanis,
Anastasios A. Politis,
Lampis C. Stavrinou,
Maria M. Gavra,
Efstathios J. Boviatsis

Affiliations

Stamatios Banos: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece; Corresponding author. Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, Rimini 1, 12462, Chaidari, Greece.
Mary Solou: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece
Ioannis Ydreos: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece
Evangelos K. Papadopoulos: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece
Georgios Savvanis: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece
Anastasios A. Politis: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece
Lampis C. Stavrinou: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece
Maria M. Gavra: Department of CT and MRI Imaging, “Agia Sofia” Children’s Hospital, Athens, Greece
Efstathios J. Boviatsis: Department of Neurosurgery and Neurotraumatology, ‘Attikon’ University General Hospital, National and Kapodistrian University, Athens Medical School, Greece

Journal volume & issue: Vol. 3
p. 101719

Abstract

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Introduction: Radiotherapy of central nervous system (CNS) is treatment against many paediatric cancers, even if it is a well-recognized risk factor for meningioma formation. An increased risk of developing secondary brain tumors like radiation-induced meningiomas (RIM) is related to irradiated patients. Research question: This retrospective study aims to present RIM cases treated in a single tertiary-hospital in Greece and compare the results with international literature and cases of sporadic meningiomas. Materials and methods: A single-centre retrospective study of all patients diagnosed between January 2012 and September 2022 with RIM after having been irradiated in CNS for paediatric cancer was undertaken through hospital’s electronic record and clinical notes, identifying baseline demographics and latency period. Results: Thirteen patients were identified with RIM diagnosis after receiving irradiation for Acute Lymphoblastic Leukaemia (69.2%), Premature Neuro-Ectodermal Tumour (23.1%), and Astrocytoma (7.7%). Median age at irradiation was 5 years old and 32 years old at RIM’s presentation. The latent period from irradiation to meningioma diagnosis was 26.23 ± 5.96 years. After surgical excision, histopathologic results showed grade I meningiomas in 12 out of thirteen cases, while only one atypical meningioma was diagnosed. Conclusion: Patients who underwent CNS-radiotherapy in childhood for any condition have an increased risk of developing secondary brain tumors such as radiation-induced meningiomas. RIMs resemble sporadic meningiomas in symptomatology, location, treatment, and histologic grade. However, long-term follow-up and regular check-ups are recommended in irradiated patients due to short latency period from irradiation to RIM development, which means younger age patients than those with sporadic meningiomas cases.

Published in Brain and Spine

ISSN: 2772-5294 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.journals.elsevier.com/brain-and-spine

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