Mucin induces CRISPR-Cas defense in an opportunistic pathogen

Gabriel Magno de Freitas Almeida; Ville Hoikkala; Janne Ravantti; Noora Rantanen; Lotta-Riina Sundberg

doi:10.1038/s41467-022-31330-3

Nature Communications (Jun 2022)

Mucin induces CRISPR-Cas defense in an opportunistic pathogen

Gabriel Magno de Freitas Almeida,
Ville Hoikkala,
Janne Ravantti,
Noora Rantanen,
Lotta-Riina Sundberg

Affiliations

Gabriel Magno de Freitas Almeida: University of Jyväskylä, Department of Biological and Environmental Science and Nanoscience Center
Ville Hoikkala: University of Jyväskylä, Department of Biological and Environmental Science and Nanoscience Center
Janne Ravantti: University of Helsinki, Molecular and Integrative Biosciences Research Programme
Noora Rantanen: University of Jyväskylä, Department of Biological and Environmental Science and Nanoscience Center
Lotta-Riina Sundberg: University of Jyväskylä, Department of Biological and Environmental Science and Nanoscience Center

DOI: https://doi.org/10.1038/s41467-022-31330-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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It is unknown what circumstances promote particular bacterial defenses against bacterial viruses (phages). Almeida & Hoikkala et al. show that mucin, derived from mucus, greatly accelerates CRISPR-Cas defenses against phage in an opportunistic pathogen.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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