Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

Alexander T. Baker; Alexander Greenshields-Watson; Lynda Coughlan; James A. Davies; Hanni Uusi-Kerttula; David K. Cole; Pierre J. Rizkallah; Alan L. Parker

doi:10.1038/s41467-019-08599-y

Nature Communications (Feb 2019)

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

Alexander T. Baker,
Alexander Greenshields-Watson,
Lynda Coughlan,
James A. Davies,
Hanni Uusi-Kerttula,
David K. Cole,
Pierre J. Rizkallah,
Alan L. Parker

Affiliations

Alexander T. Baker: Division of Cancer and Genetics, School of Medicine, Cardiff University
Alexander Greenshields-Watson: Division of Infection and Immunity, School of Medicine, Cardiff University
Lynda Coughlan: Department of Microbiology, Icahn School of Medicine at Mount Sinai
James A. Davies: Division of Cancer and Genetics, School of Medicine, Cardiff University
Hanni Uusi-Kerttula: Division of Cancer and Genetics, School of Medicine, Cardiff University
David K. Cole: Division of Infection and Immunity, School of Medicine, Cardiff University
Pierre J. Rizkallah: Division of Infection and Immunity, School of Medicine, Cardiff University
Alan L. Parker: Division of Cancer and Genetics, School of Medicine, Cardiff University

DOI: https://doi.org/10.1038/s41467-019-08599-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Adenovirus based (AdV) vectors are promising platforms for therapeutics and vaccines, but receptor usage of serotypes in clinical development remains unclear. Here, based on crystal structures and modeling, Baker et al. show that HAdV-D26/48 fiber knob protein interacts weakly with CAR but not with CD46 or DSG2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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