Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols

Abstract

A gold(I)-catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel–Crafts allylation/intramolecular hydroalkoxylation sequence. The reaction is mild, practical and tolerant of a wide variety of substituents on the phenol.

Keywords

• allylic alcohols
• chromans
• Friedel–Crafts
• gold catalysis
• heterocycles