Research Reports in Clinical Cardiology (Feb 2023)
Association Between ACE I/D Gene Polymorphism and Dyslipidemia in Hypertensive Patients with Ischemic Heart Disease Complication Among Ethiopian Population
Abstract
Addisu Melake,1,2 Nega Brhanie2 1Department of Biomedical Science, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, EthiopiaCorrespondence: Addisu Melake, Tel +251-913 94 26 54, Email [email protected]: Ischemic heart disease (IHD) is characterized by lesions in major coronary arteries produced by the atherosclerotic phenomenon. IHD is currently thought to be a complicated disorder, and studies have revealed that, in addition to the usual traditional risk factors, genetic factors also play major roles in its occurrence. Due to the intricate interactions between genetic and environmental risk factors, the link between ACE polymorphisms and other risk variables in IHD is not fully characterized. The purpose of this study was to look at how ACE gene I/D polymorphism and dyslipidemia affect the risk of developing IHD complications in hypertensive patients.Methods: A hospital-based case–control study of 70 hypertensive IHD patients and 70 age- and sex-matched healthy controls was conducted. Clinical parameters were measured to assess the associated risk factors. Deoxyribonucleic acid (DNA) was isolated from blood samples, and the ACE I/D genotypes were identified using polymerase chain reaction (PCR) and analyzed by agarose gel electrophoresis.Results: Our analysis showed that the ACE-DD genotype (OR = 2.72, 95% CL = 1.11– 6.64; P
