Nature Communications (Mar 2022)
Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
- Satria P. Sajuthi,
- Jamie L. Everman,
- Nathan D. Jackson,
- Benjamin Saef,
- Cydney L. Rios,
- Camille M. Moore,
- Angel C. Y. Mak,
- Celeste Eng,
- Ana Fairbanks-Mahnke,
- Sandra Salazar,
- Jennifer Elhawary,
- Scott Huntsman,
- Vivian Medina,
- Deborah A. Nickerson,
- Soren Germer,
- Michael C. Zody,
- Gonçalo Abecasis,
- Hyun Min Kang,
- Kenneth M. Rice,
- Rajesh Kumar,
- Noah A. Zaitlen,
- Sam Oh,
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
- José Rodríguez-Santana,
- Esteban G. Burchard,
- Max A. Seibold
Affiliations
- Satria P. Sajuthi
- Center for Genes, Environment, and Health, National Jewish Health
- Jamie L. Everman
- Center for Genes, Environment, and Health, National Jewish Health
- Nathan D. Jackson
- Center for Genes, Environment, and Health, National Jewish Health
- Benjamin Saef
- Center for Genes, Environment, and Health, National Jewish Health
- Cydney L. Rios
- Center for Genes, Environment, and Health, National Jewish Health
- Camille M. Moore
- Center for Genes, Environment, and Health, National Jewish Health
- Angel C. Y. Mak
- Department of Medicine, University of California-San Francisco
- Celeste Eng
- Department of Medicine, University of California-San Francisco
- Ana Fairbanks-Mahnke
- Center for Genes, Environment, and Health, National Jewish Health
- Sandra Salazar
- Department of Medicine, University of California-San Francisco
- Jennifer Elhawary
- Department of Medicine, University of California-San Francisco
- Scott Huntsman
- Department of Medicine, University of California-San Francisco
- Vivian Medina
- Centro de Neumología Pediátrica
- Deborah A. Nickerson
- Department of Genome Sciences, University of Washington
- Soren Germer
- New York Genome Center
- Michael C. Zody
- New York Genome Center
- Gonçalo Abecasis
- Center for Statistical Genetics, University of Michigan
- Hyun Min Kang
- Center for Statistical Genetics, University of Michigan
- Kenneth M. Rice
- Department of Biostatistics, University of Washington
- Rajesh Kumar
- Ann and Robert H. Lurie Children’s Hospital of Chicago, Department of Pediatrics, Northwestern University
- Noah A. Zaitlen
- Department of Neurology and Computational Medicine, University of California Los Angeles
- Sam Oh
- Department of Medicine, University of California-San Francisco
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
- José Rodríguez-Santana
- Centro de Neumología Pediátrica
- Esteban G. Burchard
- Department of Medicine, University of California-San Francisco
- Max A. Seibold
- Center for Genes, Environment, and Health, National Jewish Health
- DOI
- https://doi.org/10.1038/s41467-022-28973-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Understanding regulation of genes associated to disease can reveal insights into disease mechanisms. Here, the authors perform an airway epithelial transcriptome-wide association analysis to elucidate genetic determinants of airway dysfunction in asthma, identifying genetic mechanisms of mucus pathobiology.
