Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

Abstract

This is a review of our efforts toward the synthesis of a group of natural products that display noteworthy biological activity: Fredericamycin A, nothapodytine B, and topopyrones B and D. In each case, directed aromatic functionalization methodology greatly facilitated the assembly of the key molecular subunits.

Keywords

• alkaloids
• directed aromatic functionalization
• fredericamycin
• heterocyclic compounds
• lithiation
• nothapodytine
• organolithium compounds
• topopyrone