The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes

Anushweta Asthana; Parameshwaran Ramanan; Alexander Hirschi; Keelan Z. Guiley; Tilini U. Wijeratne; Robert Shelansky; Michael J. Doody; Haritha Narasimhan; Hinrich Boeger; Sarvind Tripathi; Gerd A. Müller; Seth M. Rubin

doi:10.1038/s41467-022-28094-1

Nature Communications (Jan 2022)

The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes

Anushweta Asthana,
Parameshwaran Ramanan,
Alexander Hirschi,
Keelan Z. Guiley,
Tilini U. Wijeratne,
Robert Shelansky,
Michael J. Doody,
Haritha Narasimhan,
Hinrich Boeger,
Sarvind Tripathi,
Gerd A. Müller,
Seth M. Rubin

Affiliations

Anushweta Asthana: Department of Chemistry and Biochemistry, University of California
Parameshwaran Ramanan: Department of Chemistry and Biochemistry, University of California
Alexander Hirschi: Department of Chemistry and Biochemistry, University of California
Keelan Z. Guiley: Department of Chemistry and Biochemistry, University of California
Tilini U. Wijeratne: Department of Chemistry and Biochemistry, University of California
Robert Shelansky: Department of Molecular, Cell, and Developmental Biology, University of California
Michael J. Doody: Department of Molecular, Cell, and Developmental Biology, University of California
Haritha Narasimhan: Department of Chemistry and Biochemistry, University of California
Hinrich Boeger: Department of Molecular, Cell, and Developmental Biology, University of California
Sarvind Tripathi: Department of Chemistry and Biochemistry, University of California
Gerd A. Müller: Department of Chemistry and Biochemistry, University of California
Seth M. Rubin: Department of Chemistry and Biochemistry, University of California

DOI: https://doi.org/10.1038/s41467-022-28094-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

The MuvB protein complex regulates genes that are differentially expressed through the cell cycle, yet its precise molecular function has remained unclear. Here the authors reveal MuvB associates with the nucleosome adjacent to the transcription start site of cell-cycle genes and that the tight positioning of this nucleosome correlates with MuvB-dependent gene repression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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