Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo

Michelle Reed; Anny-Claude Luissint; Veronica Azcutia; Shuling Fan; Monique N. O’Leary; Miguel Quiros; Jennifer Brazil; Asma Nusrat; Charles A. Parkos

doi:10.1038/s41467-019-12968-y

Nature Communications (Nov 2019)

Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo

Michelle Reed,
Anny-Claude Luissint,
Veronica Azcutia,
Shuling Fan,
Monique N. O’Leary,
Miguel Quiros,
Jennifer Brazil,
Asma Nusrat,
Charles A. Parkos

Affiliations

Michelle Reed: Department of Pathology, University of Michigan
Anny-Claude Luissint: Department of Pathology, University of Michigan
Veronica Azcutia: Department of Pathology, University of Michigan
Shuling Fan: Department of Pathology, University of Michigan
Monique N. O’Leary: Department of Pathology, University of Michigan
Miguel Quiros: Department of Pathology, University of Michigan
Jennifer Brazil: Department of Pathology, University of Michigan
Asma Nusrat: Department of Pathology, University of Michigan
Charles A. Parkos: Department of Pathology, University of Michigan

DOI: https://doi.org/10.1038/s41467-019-12968-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with suggested impaired cell migration in vitro.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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