Structures and Anti-Allergic Activities of Natural Products from Marine Organisms
Na Chen,
Shanshan Zhang,
Ansar Javeed,
Cuiqin Jian,
Yi Liu,
Jinlyu Sun,
Shandong Wu,
Peng Fu,
Bingnan Han
Affiliations
Na Chen
Zhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
Shanshan Zhang
Zhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
Ansar Javeed
Zhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
Cuiqin Jian
Zhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
Department of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Bingnan Han
Zhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Laboratory of Antiallergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
In recent years, allergic diseases have occurred frequently, affecting more than 20% of the global population. The current first-line treatment of anti-allergic drugs mainly includes topical corticosteroids, as well as adjuvant treatment of antihistamine drugs, which have adverse side effects and drug resistance after long-term use. Therefore, it is essential to find alternative anti-allergic agents from natural products. High pressure, low temperature, and low/lack of light lead to highly functionalized and diverse functional natural products in the marine environment. This review summarizes the information on anti-allergic secondary metabolites with a variety of chemical structures such as polyphenols, alkaloids, terpenoids, steroids, and peptides, obtained mainly from fungi, bacteria, macroalgae, sponges, mollusks, and fish. Molecular docking simulation is applied by MOE to further reveal the potential mechanism for some representative marine anti-allergic natural products to target the H1 receptor. This review may not only provide insight into information about the structures and anti-allergic activities of natural products from marine organisms but also provides a valuable reference for marine natural products with immunomodulatory activities.
