Современная онкология (Dec 2015)
Modern possibilities of targeted therapy in metastatic colorectal cancer
Abstract
Colorectal cancer (CRC) is ranked third in the world among malignant tumors in morbidity - more than 1.3 million (1 360 000 in 2012) new cases per year, and fourth in mortality - 694 000 deaths in 2012. CRC medicamentary is very important in case of this disease, and have been applying as in case of adjuvant treatment schemas and in case of metastatic disease treatment. All this allowed us significantly improve the life expectancy of the patients last decade. One of the last achievements in modern drug therapy of metastatic CRC (mCRC) is the existence of new drug - regorafenib. Regorafenib is a multi-kinase inhibitor, blocking VEGFR 1-3 and TIE-2 protein kinases, involving in tumor angiogenesis and inhibiting the growth of new blood vessels. The drug also inhibits oncogenic protein kinases: KIT, RET and RAF-1, BRAF and mutated BRAFV600E which are involved in cell proliferation and survival of cancer cells and effects on platelet-derived growth factor receptors (PDGF-R) and fibroblast growth factor receptor (FGFR) affecting the microenvironment tumor. The results of Phase III CORRECT study concerning regorafenib show the desirability of using the regorafenib as a new therapeutic option for patients with mCRC, previously have been treated for many times and have exhausted all the possibilities of drug therapy.
