Российский кардиологический журнал (Apr 2008)

Angiogenesis factor influence on myocardial morphology and function in rats with experimental myocardial infarction

  • A. S. Sisakyan,
  • V. A. Oganyan,
  • A. B. Semerdzhyan,
  • M. V. Petrosyan,
  • S. A. Sisakyan,
  • M. A. Gurevich

Journal volume & issue
Vol. 0, no. 2
pp. 63 – 66

Abstract

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In laboratory white rats, intravenous VEGF-164 injection and left coronary artery occlusion resulted in myocardial infarction development by Bay 7. In perinecrotic zone and distal areas, the increase in capillary density and exchange surface area was observed, comparing to control animals with coronary occlusion only. Therefore, VEGF-164 agent stimulated myocardial angiogenesis, with potential anti-ischemic effect, decreased necrosis area, and reduced myocardial structure reorganization.

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