Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy
Hideki Nakasone,
Mats Remberger,
Lu Tian,
Petter Brodin,
Bita Sahaf,
Fang Wu,
Jonas Mattsson,
Robert Lowsky,
Robert Negrin,
David B. Miklos,
Everett Meyer
Affiliations
Hideki Nakasone
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA;Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
Mats Remberger
Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Lu Tian
Department of Health Research and Policy, Stanford University School of Medicine, CA, USA
Petter Brodin
Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden;Science for Life Laboratory, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Bita Sahaf
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
Fang Wu
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
Jonas Mattsson
Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Robert Lowsky
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
Robert Negrin
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
David B. Miklos
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
Everett Meyer
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
Sex-mismatched hematopoietic cell transplantation is linked to increased graft-versus-host disease and mortality in myeloablative conditioning. Here we evaluated outcomes of 1,041 adult transplant recipients at two centers between 2006 and 2013 and investigated how the effect of sex-mismatching differed in myeloablative, reduced-intensity, and non-myeloablative total lymphoid irradiation with anti-thymocyte globulin conditioning. Among patients who underwent myeloablative conditioning, male recipients with female donors had increased chronic graft-versus-host disease (hazard ratio 1.83, P
