Nature Communications (Feb 2020)

Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration

  • Baotong Zhang,
  • Xinpei Ci,
  • Ran Tao,
  • Jianping Jenny Ni,
  • Xiaoyan Xuan,
  • Jamie L. King,
  • Siyuan Xia,
  • Yixiang Li,
  • Henry F. Frierson,
  • Dong-Kee Lee,
  • Jianming Xu,
  • Adeboye O. Osunkoya,
  • Jin-Tang Dong

DOI
https://doi.org/10.1038/s41467-020-14737-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The role of the Klf5 in early and postnatal prostate development and in regeneration is unclear. Here, the authors show that Klf5 acetylation regulates and maintains luminal differentiation of prostate basal progenitors and is essential following androgen-induced regeneration.