Nature Communications (Jun 2018)
PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze
- Katarzyna Niespodziana,
- Katarina Stenberg-Hammar,
- Spyridon Megremis,
- Clarissa R. Cabauatan,
- Kamila Napora-Wijata,
- Phyllis C. Vacal,
- Daniela Gallerano,
- Christian Lupinek,
- Daniel Ebner,
- Thomas Schlederer,
- Christian Harwanegg,
- Cilla Söderhäll,
- Marianne van Hage,
- Gunilla Hedlin,
- Nikolaos G. Papadopoulos,
- Rudolf Valenta
Affiliations
- Katarzyna Niespodziana
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Katarina Stenberg-Hammar
- Astrid Lindgren Children’s Hospital, Karolinska University Hospital
- Spyridon Megremis
- Division of Infection, Immunity & Respiratory Medicine, University of Manchester
- Clarissa R. Cabauatan
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Kamila Napora-Wijata
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Phyllis C. Vacal
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Daniela Gallerano
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Christian Lupinek
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Daniel Ebner
- Phadia Austria GmbH, Part of Thermo Fisher Scientific ImmunoDiagnostics
- Thomas Schlederer
- Phadia Austria GmbH, Part of Thermo Fisher Scientific ImmunoDiagnostics
- Christian Harwanegg
- Phadia Austria GmbH, Part of Thermo Fisher Scientific ImmunoDiagnostics
- Cilla Söderhäll
- Department of Women’s and Children’s Health, Karolinska Institutet
- Marianne van Hage
- Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital
- Gunilla Hedlin
- Astrid Lindgren Children’s Hospital, Karolinska University Hospital
- Nikolaos G. Papadopoulos
- Division of Infection, Immunity & Respiratory Medicine, University of Manchester
- Rudolf Valenta
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-018-04591-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Rhinovirus (RV) infections can trigger acute exacerbations of respiratory diseases. Here, Niespodziana et al. develop a PreDicta chip that identifies the culprit RV strain from small blood samples and show that RV-A and RV-C strains are associated with most severe symptoms.
