Cohort profile: A population-based record linkage platform to address critical epidemiological evidence gaps in respiratory syncytial virus and other respiratory infections

Mohinder (Minda) Sarna; Belaynew Taye; Huong Le; Fiona Giannini; Kathryn Glass; Christopher Blyth; Peter Richmond; Rebecca Glauert; Avram Levy; Hannah Moore

doi:10.23889/ijpds.v9i2.2376

International Journal of Population Data Science (Apr 2024)

Cohort profile: A population-based record linkage platform to address critical epidemiological evidence gaps in respiratory syncytial virus and other respiratory infections

Mohinder (Minda) Sarna,
Belaynew Taye,
Huong Le,
Fiona Giannini,
Kathryn Glass,
Christopher Blyth,
Peter Richmond,
Rebecca Glauert,
Avram Levy,
Hannah Moore

Affiliations

Mohinder (Minda) Sarna: Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Population Health, Curtin University, Bentley, WA, Australia
Belaynew Taye: ORCiD; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Population Health, Curtin University, Bentley, WA, Australia
Huong Le: ORCiD; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Population Health, Curtin University, Bentley, WA, Australia
Fiona Giannini: ORCiD; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia
Kathryn Glass: Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; National Centre for Epidemiology and Population Health, ANU College of Health and Medicine, Australian National University, Canberra, ACT, Australia
Christopher Blyth: Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Medicine, University of Western Australia, Nedlands, WA, Australia; Department of Paediatric Infectious Diseases, Perth Children's Hospital, WA, Australia
Peter Richmond: Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Medicine, University of Western Australia, Nedlands, WA, Australia; Department of Paediatric Infectious Diseases, Perth Children's Hospital, WA, Australia
Rebecca Glauert: Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Population and Global Health, University of Western Australia, Nedlands, WA, Australia
Avram Levy: ORCiD; Pathogen Genomics and Surveillance Unit, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Perth, WA, Australia; School of Biomedical Sciences, University of Western Australia, Nedlands, Perth, WA, Australia
Hannah Moore: ORCiD; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia; School of Population Health, Curtin University, Bentley, WA, Australia

DOI: https://doi.org/10.23889/ijpds.v9i2.2376
Journal volume & issue: Vol. 9, no. 2

Abstract

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Introduction The Western Australia (WA) Respiratory Infections Linked Data Platform is a population-based cohort established to investigate the epidemiology of RSV and other respiratory infections in children aged 0-10 years, incorporating microbiological testing patterns, hospital admissions, emergency department presentations, and socio-demographic data. Methods The cohort was formed through individual linkages between datasets from the WA Department of Health including the Birth and Death Registry, Midwives Notification System (MNS), Hospital Morbidity Data Collection, Emergency Department Data Collection, WA Notifiable Diseases Database, WA Register of Developmental Anomalies, WA Cerebral Palsy Register, WA Antenatal Vaccination Database, WA Family Connections, and PathWest Respiratory Virus Surveillance Data. Hospitalisations and emergency department presentations were temporally linked to routine respiratory viral surveillance data. Results The cohort consists of 368,830 WA births between 1 January 2010 and 31 December 2020 with accompanying perinatal and demographic data, and with secondary care follow-up to 30 June 2022. Of these births, 24,660 (6.7%) identify as Aboriginal. A total of 4,077 (1.1%) children died from all causes during the study period (2010-2020), and 9.2% (33,818) of children were born preterm (<37 weeks). Conclusion The Respiratory Infections Linked Data Platform enables epidemiological investigations, identifying virus-specific risk groups, risk factors, clinical presentation, viral testing patterns, long-term impacts and accurate measures of viral incidence rates in risk and population sub-groups This will not only aid in the calculation of cost-effectiveness estimates of interventions such as immunisations, but also provide guidance for design and implementation of such programs to priority groups. The Respiratory Infections Linked Data Platform will also enable evaluation of the direct and indirect effects of maternal and infant vaccines and new therapeutics. Analyses using this platform will also generate epidemiological data needed for other respiratory viruses on the vaccine pipeline such as parainfluenza virus and human metapneumovirus.

Published in International Journal of Population Data Science

ISSN: 2399-4908 (Online)
Publisher: Swansea University
Country of publisher: United Kingdom
LCC subjects: Social Sciences: Economic theory. Demography: Demography. Population. Vital events
Website: https://ijpds.org

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